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Inventi Impact: Planta Activa

Articles

  • Inventi:ppa/30747/19
    Chemical Composition, Antioxidant and Cytotoxicity Activities of Leaves, Bark, Twigs and Oleo-Resin of Dipterocarpus alatus
    Research 2020 : January - March
    Chawalit Yongram, Bunleu Sungthong, Ploenthip Puthongking, Natthida Weerapreeyakul

    Dipterocarpus alatus (Dipterocarpaceae) is a medicinal plant whose use is well known for\nthe treatment of genito-urinary diseases. However, there is no report of its cytotoxic potential. In this\nstudy, the chemical composition, antioxidant and cytotoxic activities of extracts of the leaves, bark,\ntwigs and oleo-resin from D. alatus are investigated. Cytotoxicity was measured by the neutral red\n(NR) assay against HCT116, SKLU1, SK-MEL2, SiHa and U937 cancer cell lines and antioxidant\ncapacity was evaluated by DPPH, ABTS radical scavenging, and ferric reducing antioxidant power\n(FRAP) assays. The chemical composition was analyzed by gas chromatography-mass spectrometry\n(GC-MS). Leaf, bark and twig extracts exhibited stronger antioxidant activity than oleo-resin, with bark\nextract showing the highest antioxidant activity and the highest total phenolic content. All samples\nshowed more cytotoxic activity against the U937 cell line than HCT116, SKLU1, SK-MEL2 and SiHa\ncells with oleo-resin being more cytotoxic than melphalan against U937 cells. Chemical composition\nanalysis of oleo-resin by GC-MS showed that the major components were sesquiterpenes, namely�����

    How to Cite this Article
    Attribution/ CC Compliant Citation: Yongram, Chawalit, et al. \"Chemical Composition, Antioxidant and Cytotoxicity\nActivities of Leaves, Bark, Twigs and Oleo-Resin of Dipterocarpus alatus.\" Molecules 24.17 (2019): 3083.\nhttps://doi:10.3390/molecules24173083\nhttp://creativecommons.org/licenses/by/4.0/\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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